Linkage mapping of sex-specific differences

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Linkage mapping of sex-specific differences.

Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular marker...

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Evolutionary theory predicts that the sex linkage of sexually selected traits can influence the direction and rate of evolutionary change, and also itself be subject to selection. Theory abounds on how sex-specific selection, mate choice, or other phenomena should favor different types of sex-linked inheritance, yet evidence in nature remains limited. Here, we use hormone assays in Trinidadian ...

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Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE

MOTIVATION Sex-specific marker maps have become increasingly available. We have implemented the usage of sex-specific recombination frequencies in the GENEHUNTER-MODSCORE program that performs multipoint linkage analysis. Furthermore, we have devised a consistent method to choose the combinations of male and female genetic positions at which linkage scores should be calculated. Marker coordinat...

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Sex Differences and Symptoms of Acute Coronary Syndrome

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ژورنال

عنوان ژورنال: Genetical Research

سال: 2002

ISSN: 0016-6723,1469-5073

DOI: 10.1017/s0016672301005389